Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis
Xie W, Su F, Wang G, Peng Z, Xu Y
Published in Frontiers in Pharmacology
Methodology
Systematic review and meta-analysis of randomised controlled trials of berberine in type 2 diabetes across eight databases, stratified by baseline fasting plasma glucose and HbA1c
Key Findings
Berberine lowered fasting plasma glucose and HbA1c, with larger effects in patients with higher baseline glycaemia and no signal of hypoglycaemia.
Conclusions
Berberine has a glucose-dependent glucose-lowering effect in type 2 diabetes.
Limitations
Predominantly Chinese trials; variable trial quality; short durations; heterogeneity across doses.
Supplements Studied
the glucose-lowering effects of berberine are only under hyperglycemic conditions or in a high-glucose-dependent manner
Berberine lowered fasting plasma glucose and HbA1c in randomized trials of type 2 diabetes.
Outcomes Measured
In order to shed light on the glucose-lowing effects of berberine in type 2 diabetes with different baseline fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c), we conducted a meta-analysis of randomized controlled trials.
Berberine lowered fasting plasma glucose and HbA1c with effects comparable to some oral hypoglycaemic agents in small trials.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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