Fisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H
Published in EBioMedicine
Abstract
Groundbreaking study identifying fisetin as a potent senolytic agent that selectively eliminates senescent cells. Demonstrated extension of healthspan and lifespan in progeroid mice with significant tissue-specific senescent cell clearance.
Methodology
Preclinical screen of flavonoids for senolytic activity in murine and human cells, followed by lifespan studies in aged mice.
Key Findings
Fisetin was the most potent senolytic among tested flavonoids, reduced senescent cell burden in multiple tissues and extended median and maximum lifespan in mice.
Conclusions
Fisetin is a promising senotherapeutic, but the evidence is entirely preclinical.
Limitations
Animal and cell-culture only; no human efficacy data; doses used far exceed dietary intake.
Supplements Studied
Fisetin was the most potent senolytic of the flavonoids tested and extended median and maximum lifespan in aged mice.
Outcomes Measured
Fisetin identified as a potent senolytic agent that selectively eliminates senescent cells, demonstrating extension of healthspan and lifespan in progeroid mice with significant tissue-specific senescent cell clearance.
Study Details
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