Fiber Supplementation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Staudacher HM, Rucco V, Mancell S, Dimidi E, Whelan K
Published in Gastroenterology
Methodology
Systematic review and meta-analysis of RCTs of fiber supplements against a suitable placebo in adults with IBS; 30 RCTs (1,904 people); PROSPERO-registered. Searches to April 2026.
Key Findings
16 RCTs (n = 1,293) reported clinical response: 52% on fiber vs 44% on control (RR 1.21, 95% CI 1.03-1.41; P = 0.02; I2 = 38%), with a benefit for psyllium (RR 1.53, 95% CI 1.06-2.19). 9 RCTs (n = 497) reporting overall symptom scores found no significant effect (SMD -0.25, 95% CI -0.67 to 0.17; I2 = 78%), except for beta-galacto-oligosaccharides.
Conclusions
Fiber supplementation, and psyllium specifically, leads to clinical response in IBS. Future trials should report by IBS subtype.
Limitations
Subtype analysis was not possible for most outcomes; symptom-score results were highly heterogeneous; fiber types pooled (bran, psyllium, inulin-type fructans, GOS) behave differently.
Supplements Studied
Fiber supplementation, and psyllium specifically, leads to clinical response in IBS
Fiber supplementation, and psyllium specifically, leads to clinical response in IBS
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.