Vitamin D and T-cell activation: 25-hydroxyvitamin D is required for human T-cell antigen receptor signalling
von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C
Published in Nature Immunology
Methodology
Mechanistic human immunology study of vitamin D receptor and phospholipase C-gamma1 signalling in naive T cells exposed to varying vitamin D levels.
Key Findings
Naive T cells failed to activate without vitamin D, which was required to induce phospholipase C-gamma1 and antigen receptor signalling.
Conclusions
Vitamin D sufficiency is a prerequisite for T-cell activation.
Limitations
Ex vivo human cells; no clinical outcome measured.
Supplements Studied
Naive T cells failed to activate without vitamin D, which was required to induce antigen receptor signalling
Outcomes Measured
Naive T cells failed to activate without vitamin D, which was required to induce phospholipase C-gamma1 and antigen receptor signalling
Study Details
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