Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials
van Die MD, Burger HG, Teede HJ, Bone KM
Published in Planta Medica
Methodology
Systematic review of 12 randomised controlled trials of Vitex agnus-castus in premenstrual syndrome, premenstrual dysphoric disorder, latent hyperprolactinaemia and infertility.
Key Findings
Most trials favoured Vitex over placebo for premenstrual syndrome and cyclical mastalgia; evidence for infertility and cycle regulation was preliminary.
Conclusions
Vitex has reasonable evidence for premenstrual syndrome and mastalgia, weaker evidence for reproductive endpoints.
Limitations
Heterogeneous preparations and doses; several trials at moderate risk of bias.
Supplements Studied
Most trials favoured Vitex over placebo for premenstrual syndrome and cyclical mastalgia.
Outcomes Measured
Evidence for Vitex on cycle regulation and reproductive endpoints remains preliminary.
Related Health Concerns
Study Details
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