Effect of exogenous melatonin on endogenous melatonin secretion and circadian phase: a systematic review
Burgess HJ, Emens JS
Published in Current Sleep Medicine Reports
Methodology
Systematic review of trials using dim light melatonin onset to assess how exogenous melatonin timing shifts endogenous circadian melatonin rhythms.
Key Findings
Low-dose melatonin taken in the early evening advanced dim light melatonin onset; exogenous dosing did not suppress endogenous production long term.
Conclusions
Melatonin timing, not dose, drives shifts in the endogenous melatonin rhythm.
Limitations
Small laboratory studies; limited real-world follow-up.
Supplements Studied
Low-dose melatonin taken in the early evening advanced dim light melatonin onset
Outcomes Measured
Low-dose melatonin taken in the early evening advanced dim light melatonin onset
Study Details
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