The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms
Di Stefano M, Miceli E, Gotti S
Published in Digestive Diseases and Sciences
Methodology
Randomised double-blind placebo-controlled crossover challenge in 8 healthy volunteers given 300 or 1200 GalU alpha-galactosidase with a 420 g cooked bean meal
Key Findings
The 1200 GalU dose significantly reduced breath hydrogen excretion and flatulence severity; both doses reduced total symptom score
Conclusions
Exogenous enzyme activity measurably changes substrate handling in the gut lumen in a dose-dependent way
Limitations
Only 8 volunteers; single test meal
Supplements Studied
The administration of 1200 GalU of alpha-galactosidase induced a significant reduction of both breath hydrogen excretion and severity of flatulence.
Outcomes Measured
The administration of 1200 GalU of alpha-galactosidase induced a significant reduction of both breath hydrogen excretion and severity of flatulence.
The administration of 1200 GalU of alpha-galactosidase induced a significant reduction of both breath hydrogen excretion and severity of flatulence.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.