Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis
Shang Y, Song N, He R, Wu M
Published in Advances in Nutrition
Methodology
Systematic review and meta-analysis of 20 randomized clinical trials of antioxidant supplementation in women with ovarian aging (PROSPERO CRD42022359529)
Key Findings
Antioxidants increased retrieved oocyte numbers and high-quality embryo rates, reduced gonadotropin dose and improved clinical pregnancy rates. CoQ10 outperformed melatonin, myo-inositol and vitamins; benefit was clearest at lower doses (around 30 mg/day for 3 months pre-cycle) and in women under 35 with diminished ovarian reserve.
Conclusions
Antioxidants appear to be a safe complementary option in ovarian aging, with CoQ10 the best-supported agent, though effects are mostly on intermediate IVF endpoints.
Limitations
Heterogeneous agents and doses; several small trials; live birth rarely reported
Supplements Studied
Small improvements were observed with other drugs
In terms of antioxidant types, coenzyme Q10 (CoQ10) tended to be more effective than melatonin, myo-inositol, and vitamins
Outcomes Measured
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.