Inositol for subfertile women with polycystic ovary syndrome
Showell MG, Mackenzie-Proctor R, Jordan V, Hodgson R, Farquhar C
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review of randomised controlled trials of myo-inositol or D-chiro-inositol in subfertile women with PCOS undergoing fertility treatment or trying to conceive.
Key Findings
Evidence was of very low quality and it remains uncertain whether inositol improves live birth or clinical pregnancy rates, although there was some evidence of improved ovulation and no increase in adverse events.
Conclusions
The effect of inositol on live birth in subfertile women with PCOS is uncertain.
Limitations
Very low certainty evidence; small trials at risk of bias; sparse reporting of live birth.
Supplements Studied
It remains uncertain whether inositol improves live birth or clinical pregnancy rates, although there was some evidence of improved ovulation.
Outcomes Measured
We are uncertain whether MI improves live birth rates when compared to standard treatment among women undergoing IVF (OR 2.42, 95% CI 0.75 to 7.83; P = 0.14; 2 RCTs; 84 women; I² = 0%)
It remains uncertain whether inositol improves live birth or clinical pregnancy rates.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Cochrane Collaboration
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