Effect of administration of β-hydroxy-β-methyl butyrate-enriched formula after liver transplantation: A pilot randomized controlled trial
Kamo N, Kaido T, Uozumi R, Ito T
Published in Nutrition
Methodology
Pilot randomised controlled trial in 33 adult living-donor liver transplant recipients given two daily packs of calcium-HMB 1500 mg, L-arginine 7000 mg and L-glutamine 7000 mg for 30 postoperative days alongside rehabilitation, with grip strength at 2 months as primary endpoint
Key Findings
The HMB/arginine/glutamine formula was tested for postoperative sarcopenia, grip strength and skeletal muscle index recovery after transplantation in a pilot setting.
Conclusions
HMB-enriched formulas are a plausible adjunct for muscle recovery after major illness, but pilot-scale evidence is preliminary.
Limitations
Very small single-centre pilot, open design, transplant-specific population.
Supplements Studied
Patients in the HMB group received two packs of HMB-rich nutrients per day, which contained calcium-HMB (1500 mg), l-arginine (7000 mg), and l -glutamine (7000 mg) per pack
Patients in the HMB group received two packs of HMB-rich nutrients per day, which contained calcium-HMB (1500 mg), l-arginine (7000 mg), and l -glutamine (7000 mg) per pack
Patients in the HMB group received two packs of HMB-rich nutrients per day, which contained calcium-HMB (1500 mg), l-arginine (7000 mg), and l -glutamine (7000 mg) per pack
Outcomes Measured
These comorbidities may prevent early recovery after surgery.
Study Details
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Disclosures
Funding
Academic/hospital-funded
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