Circadian-Based Therapies for Circadian Rhythm Sleep-Wake Disorders
Burgess HJ, Emens JS
Published in Current Sleep Medicine Reports, Vol. 2 (3), pp. 158-165
Methodology
Systematic review of trials using dim light melatonin onset to assess how exogenous melatonin timing shifts endogenous circadian melatonin rhythms.
Key Findings
Low-dose melatonin taken in the early evening advanced dim light melatonin onset; exogenous dosing did not suppress endogenous production long term.
Conclusions
Melatonin timing, not dose, drives shifts in the endogenous melatonin rhythm.
Limitations
Small laboratory studies; limited real-world follow-up.
Supplements Studied
Low-dose melatonin taken in the early evening advanced dim light melatonin onset
Outcomes Measured
Low-dose melatonin taken in the early evening advanced dim light melatonin onset
Study Details
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