observational
    2004

    Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR

    McKeown-Eyssen G, Baines C, Cole DE

    Published in International Journal of Epidemiology

    Methodology

    Case-control genotyping study of detoxification enzyme polymorphisms in people with multiple chemical sensitivity.

    Key Findings

    Certain CYP2D6 and NAT2 genotype combinations were more frequent in cases, suggesting altered chemical metabolism in a subgroup.

    Conclusions

    A metabolic subgroup may exist, but findings have not been consistently replicated.

    Limitations

    Single case-control study; multiple comparisons; self-reported diagnosis.

    Related Health Concerns

    Chemical Sensitivity

    Study Details

    Year:2004
    Sample Size:406
    Quality Score:6/10

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