Glutathione as a depigmenting agent: an overview of clinical evidence
Sonthalia S, Jha AK, Lallas A, Jain G, Jakhar D
Published in International Journal of Dermatology
Methodology
Narrative and systematic overview of clinical trials of oral, topical and intravenous glutathione for skin lightening
Key Findings
A few small randomised trials reported modest reductions in melanin index with oral or topical glutathione, but effects were short-lived and intravenous use carries serious safety risks.
Conclusions
Evidence for glutathione as a skin-lightening agent is weak and intravenous use is unsafe.
Limitations
Few controlled trials, short follow-up, industry involvement.
Supplements Studied
Evidence for the skin-lightening efficacy of glutathione is limited to small studies with short follow-up, and the intravenous route carries significant safety concerns.
Study Details
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