rct
2016
High Quality
Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial
Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ
Published in JAMA Internal Medicine
Methodology
One-year double-blind RCT comparing 24 000 IU/month, 60 000 IU/month and 24 000 IU plus calcifediol in seniors with prior fall.
Key Findings
Higher monthly doses improved 25(OH)D levels but did not improve lower extremity function and were associated with a significantly higher rate of falls (66.9% vs 47.9%).
Conclusions
High-dose intermittent vitamin D increases rather than reduces falls.
Limitations
Single centre, modest sample, intermittent high-dose regimen only.
Supplements Studied
Vitamin D
Vitamin
High monthly doses were associated with a significantly higher rate of falls (66.9% vs 47.9%).
Related Health Concerns
Study Details
Year:2016
Sample Size:200
Quality Score:8/10
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.