Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
Richie JP, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE
Published in European Journal of Nutrition
Methodology
Six-month randomised placebo-controlled trial of oral glutathione 250 mg or 1000 mg daily in healthy adults with measurement of blood, erythrocyte and buccal glutathione
Key Findings
Blood glutathione rose 30-35% and buccal cell levels 250% with the high dose; natural killer cell cytotoxicity doubled at 3 months, with levels returning to baseline after washout.
Conclusions
Long-term oral glutathione can raise body stores of glutathione in healthy adults.
Limitations
Modest sample; funded in part by a supplement manufacturer; clinical endpoints not assessed.
Supplements Studied
Oral glutathione supplementation for six months resulted in increases in body stores of glutathione of 30-35% in blood and 260% in buccal cells at the higher dose.
Outcomes Measured
Six months of oral glutathione increased body stores of glutathione by 30-35% in blood and enhanced natural killer cell cytotoxicity.
At 6 months, mean GSH levels increased 30-35 % in erythrocytes, plasma and lymphocytes and 260 % in buccal cells in the high-dose group (P < 0.05).
Study Details
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