Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo
Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, Breyer BN, Garcia MM, Lin CS, Lue TF
Published in Journal of Sexual Medicine
Methodology
In vitro phosphodiesterase inhibition assays and in vivo rat cavernous nerve injury model testing purified icariin and derivatives
Key Findings
Icariin inhibited PDE-5 with modest potency and improved erectile recovery and nerve regeneration in the rat model.
Conclusions
Icariin has genuine but weak PDE-5 activity demonstrated only in laboratory and animal models.
Limitations
No human data; potency far below prescription PDE-5 inhibitors.
Supplements Studied
Icariin inhibited PDE-5 with modest potency and improved erectile recovery in the rat model.
Outcomes Measured
Icariin inhibited PDE-5 with modest potency and improved erectile recovery in the rat model.
Related Health Concerns
Study Details
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