Dietary nitrate supplementation and exercise tolerance in patients with heart failure with reduced ejection fraction
Hirai DM, Zelt JT, Jones JH, Castanhas LG, Bentley RF, Earle W
Published in American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Methodology
Double-blind randomized crossover trial of nitrate-rich versus nitrate-depleted beetroot juice for 9 days in patients with left ventricular ejection fraction 40% or below, with constant-load cardiopulmonary exercise testing
Key Findings
Nitrate supplementation raised plasma nitrite significantly but produced no consistent improvement in exercise tolerance or muscle oxygenation in HFrEF patients.
Conclusions
Short-term dietary nitrate increases nitrite availability without reliably improving exercise tolerance in HFrEF.
Limitations
Very small sample (10 completers), short 9-day supplementation, single-center.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.