meta_analysis
    2012
    High Quality

    Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression

    Sarris J, Mischoulon D, Schweitzer I

    Published in Journal of Clinical Psychiatry

    Methodology

    Meta-analyses of RCTs of omega-3 adjunctive therapy in bipolar depression and mania.

    Key Findings

    Significant benefit of adjunctive omega-3 for bipolar depressive symptoms (Hedges g 0.34); no significant effect on manic symptoms.

    Conclusions

    Adjunctive omega-3 may help the depressive pole of bipolar disorder but not mania.

    Limitations

    Few small trials, varying EPA/DHA ratios, adjunctive designs only.

    Supplements Studied

    Adjunctive omega-3 benefited bipolar depressive symptoms (Hedges g 0.34) but not mania.

    Outcomes Measured

    Depression Symptom Reduction

    Adjunctive omega-3 significantly reduced bipolar depressive symptoms (Hedges g 0.34).

    Mood Stabilization

    Adjunctive omega-3 helped bipolar depression but not manic symptoms.

    Related Health Concerns

    Bipolar Disorder
    Depression

    Study Details

    Year:2012
    Sample Size:291
    Quality Score:7/10

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