rct
2024
Cognitive protection and brain entropy changes from omega-3 polyunsaturated fatty acids supplement in late-life depression: a 52-week randomized controlled trial
Chang JP, et al
Published in J Affect Disord
Key Findings
Omega-3 PUFA supplementation over 52 weeks mitigated cognitive decline in late-life depression, with changes in inflammatory markers and brain entropy.
Conclusions
Omega-3 PUFAs may deter cognitive decline through anti-inflammatory mechanisms.
Limitations
Small sample, single centre, surrogate imaging endpoints.
Supplements Studied
Omega-3 Fatty Acids
Fatty Acid
Omega-3 PUFAs supplement may mitigate cognitive decline in LLD through anti-inflammatory mechanisms.
Outcomes Measured
Omega-3 PUFAs supplement may mitigate cognitive decline in LLD through anti-inflammatory mechanisms and modulation of brain entropy.
Related Health Concerns
Study Details
Year:2024
Duration:52 weeks
Quality Score:6/10
Access Study
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