Lactobacillus plantarum 299v supplementation improves vascular endothelial function and reduces inflammatory biomarkers in men with stable coronary artery disease
Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, Ying R, Tanner MJ, Kakarla M, Baker JE, Widlansky ME
Published in Circulation Research
Methodology
Randomised double-blind placebo-controlled trial of L. plantarum 299v for 6 weeks in men with stable coronary artery disease, measuring brachial artery flow-mediated dilation
Key Findings
Flow-mediated dilation improved significantly and circulating IL-8, IL-12 and leptin fell with L. plantarum 299v versus placebo.
Conclusions
L. plantarum 299v improves endothelial function and systemic inflammation in coronary disease.
Limitations
Men only; small sample; surrogate vascular endpoint.
Supplements Studied
Flow-mediated dilation improved significantly and circulating IL-8, IL-12 and leptin fell with L. plantarum 299v versus placebo.
Outcomes Measured
Flow-mediated dilation improved significantly and circulating IL-8, IL-12 and leptin fell with L. plantarum 299v versus placebo.
Related Health Concerns
Study Details
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