Vitamin A and mucosal barrier immunity: a systematic review of supplementation trials
Huang Z, Liu Y, Qi G, Brand D, Zheng SG
Published in Journal of Clinical Medicine
Methodology
Review of human trials and mechanistic data on vitamin A status, gut-homing lymphocytes and mucosal IgA production.
Key Findings
Vitamin A supplementation restored mucosal IgA responses and epithelial barrier integrity in deficient populations; benefit in replete populations was unclear.
Conclusions
Vitamin A is required for mucosal immunity but supplementation helps mainly where deficiency exists.
Limitations
Mostly deficiency-focused populations; limited data in well-nourished adults.
Supplements Studied
Vitamin A supplementation restored mucosal IgA responses and epithelial barrier integrity
Outcomes Measured
Vitamin A supplementation restored mucosal IgA responses and epithelial barrier integrity in deficient populations
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.