Adjunctive nutraceuticals for depression: a systematic review and meta-analyses
Sarris J, Murphy J, Mischoulon D
Published in American Journal of Psychiatry
Methodology
Systematic review and meta-analyses of RCTs of nutraceuticals added to antidepressant or mood-stabiliser therapy.
Key Findings
Strongest adjunctive evidence for omega-3 (SMD 0.61), SAMe, methylfolate and vitamin D; mixed or negative results for zinc, folic acid and inositol.
Conclusions
A small set of nutraceuticals have replicated adjunctive antidepressant effects; most do not.
Limitations
Publication bias likely; unipolar depression dominates the trial pool.
Supplements Studied
Strongest adjunctive antidepressant evidence was for omega-3 (SMD 0.61).
Strongest adjunctive evidence for omega-3 (SMD 0.61), SAMe, methylfolate and vitamin D; mixed or negative results for zinc, folic acid and inositol.
Outcomes Measured
Strongest adjunctive antidepressant evidence for omega-3, SAMe, methylfolate and vitamin D.
Related Health Concerns
Study Details
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