Clinical use of Hypericum perforatum (St John's wort) in depression: a meta-analysis
Ng QX, Venkatanarayanan N, Ho CY
Published in Journal of Affective Disorders
Methodology
Meta-analysis of 27 randomized trials comparing St John's wort with SSRIs in mild to moderate depression.
Key Findings
Remission and response rates were comparable to SSRIs, with significantly lower discontinuation and adverse event rates.
Conclusions
St John's wort is comparable to SSRIs for mild to moderate depression with better tolerability.
Limitations
Short trial durations; little data on severe depression or long-term relapse.
Supplements Studied
St John's wort is comparable to SSRIs for mild to moderate depression with better tolerability.
Outcomes Measured
Remission and response rates were comparable to SSRIs.
Related Health Concerns
Study Details
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