Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis
Lin G, Li X, Jin Yie SL, Xu L
Published in Annals of Medicine
Methodology
Meta-analysis of six RCTs (1529 women) of CoQ10 pretreatment before IVF/ICSI in diminished ovarian reserve, with sensitivity analyses.
Key Findings
CoQ10 pretreatment was associated with higher clinical pregnancy rate (OR 1.84, 95% CI 1.33-2.53), more oocytes retrieved, and lower cycle cancellation and miscarriage rates.
Conclusions
CoQ10 pretreatment may improve IVF/ICSI outcomes in women with diminished ovarian reserve, though live birth data remain limited.
Limitations
Few trials, mostly single-centre; live birth not consistently reported; risk of bias in included RCTs.
Supplements Studied
CoQ10 pretreatment was significantly correlated with elevated clinical pregnancy rate (OR = 1.84, 95%CI [1.33, 2.53], p = 0.0002)
Outcomes Measured
The review of available evidence suggested that CoQ10 pretreatment was significantly correlated with elevated clinical pregnancy rate (OR = 1.84, 95%CI [1.33, 2.53])
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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