crossover
    2012
    High Quality

    Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study

    Enseleit F, Sudano I, Periat D, Winnik S, Wolfrum M, Flammer AJ, Frohlich GM, Kaiser P, Hirt A, Haile SR, Krasniqi N, Matter CM, Uhlenhut K, Hogger P, Neidhart M, Luscher TF, Ruschitzka F, Noll G

    Published in European Heart Journal

    Methodology

    Independent double-blind randomized placebo-controlled crossover trial of Pycnogenol 200 mg/day for 8 weeks in stable coronary artery disease

    Key Findings

    Pycnogenol improved flow-mediated dilation but did not change oxidative stress markers, inflammation, platelet function or blood pressure

    Conclusions

    Pycnogenol improved endothelial function without affecting other cardiovascular markers

    Limitations

    Surrogate endpoint; short duration; single centre

    Supplements Studied

    Pycnogenol improved flow-mediated dilation but did not change oxidative stress markers, inflammation, platelet function or blood pressure

    Outcomes Measured

    Endothelial Function

    Pycnogenol improved flow-mediated dilation but did not change oxidative stress markers, inflammation, platelet function or blood pressure

    Related Health Concerns

    Coronary Artery Disease

    Study Details

    Year:2012
    Sample Size:23
    Duration:8 weeks
    Quality Score:7/10

    Access Study

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