The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review
Li MF, Zhou XM, Li XL
Published in Evidence-Based Complementary and Alternative Medicine
Methodology
Meta-analysis of randomised trials comparing berberine with metformin or placebo in women with PCOS and insulin resistance, assessing metabolic and endocrine outcomes.
Key Findings
Berberine improved insulin resistance (HOMA-IR), lipid profile and waist-to-hip ratio comparably to metformin, with a lower incidence of gastrointestinal side effects in some trials.
Conclusions
Berberine is a plausible alternative insulin sensitiser in PCOS with insulin resistance, though evidence remains limited.
Limitations
Few trials, small samples, short follow-up, limited data on pregnancy and live-birth outcomes.
Supplements Studied
Berberine improved insulin resistance, lipid profile and waist-to-hip ratio in women with polycystic ovary syndrome and insulin resistance.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Academic research funding
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.