Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-Analysis
Calderon-Ospina CA, Nava-Mesa MO, Arbelaez Ariza CE
Published in Pain Medicine
Key Findings
Adding B1/B6/B12 to diclofenac produced faster and greater analgesia in low back pain than diclofenac alone, allowing shorter NSAID courses.
Conclusions
B-vitamin complex is a reasonable synergistic adjunct to NSAIDs in low back pain, though included trials had risk of bias.
Supplements Studied
Cumulative evidence suggests an analgesic effect of thiamine, pyridoxine, and cyanocobalamin (TPC) in monotherapy, and also when combined with nonsteroidal anti-inflammatory drugs (NSAIDs), particularly diclofenac, in a synergistic manner.
Cumulative evidence suggests an analgesic effect of thiamine, pyridoxine, and cyanocobalamin (TPC) in monotherapy, and also when combined with nonsteroidal anti-inflammatory drugs (NSAIDs), particularly diclofenac, in a synergistic manner.
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Study Details
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