Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta-Analysis
Schweiger V, Martini A, Bellamoli P, Donadello K, Schievano C, Del Balzo G, Sarzi-Puttini P, Beggio M, Nizzero M, Perlini C, Polati E
Published in Nutrients
Methodology
Systematic review and meta-analysis of studies using micronized/ultramicronized PEA for at least 60 days in chronic pain
Key Findings
Prolonged treatment with micron-size PEA was associated with sustained reductions in pain intensity without safety signals
Conclusions
Extended PEA treatment maintains analgesic benefit over time
Limitations
Few controlled long-term trials, publication and sponsor bias likely
Supplements Studied
Prolonged treatment with micron-size PEA was associated with sustained reductions in pain intensity without safety signals
Related Health Concerns
Study Details
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