Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC
Published in Journal of Nutrition
Methodology
Prospective population cohort of 4,807 adults aged 55 and older followed for 7-10 years with dietary vitamin K intake assessment.
Key Findings
Highest tertile of menaquinone intake was associated with reduced coronary heart disease mortality, all-cause mortality and severe aortic calcification; phylloquinone intake showed no association.
Conclusions
Dietary menaquinone intake is inversely associated with coronary heart disease in older adults.
Limitations
Observational design with residual confounding; dietary estimates of K2 are imprecise.
Supplements Studied
High dietary menaquinone intake was associated with reduced coronary heart disease mortality and aortic calcification.
Highest tertile of menaquinone intake was associated with reduced coronary heart disease mortality, all-cause mortality and severe aortic calcification; phylloquinone intake showed no association.
Related Health Concerns
Study Details
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