observational
    2001

    Disposition and metabolism of the flavonoid chrysin in normal volunteers

    Walle T, Otake Y, Brubaker JA, Walle UK, Halushka PV

    Published in British Journal of Clinical Pharmacology

    Methodology

    Pharmacokinetic study in healthy volunteers given a single 400 mg oral dose of chrysin with plasma and urine sampling.

    Key Findings

    Oral chrysin was extensively conjugated in the gut and liver; systemic bioavailability was extremely low.

    Conclusions

    Chrysin has extremely poor oral bioavailability, which makes meaningful systemic effects from oral supplements unlikely.

    Limitations

    Very small sample, single dose, healthy volunteers only, no clinical endpoints.

    Supplements Studied

    Oral chrysin was extensively conjugated and systemic bioavailability was extremely low.

    Study Details

    Year:2001
    Sample Size:12
    Duration:1 weeks
    Quality Score:5/10

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