A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer
Alumkal JJ, Slottke R, Schwartzman J, Cherala G, Munar M, Graff JN, Beer TM, Ryan CW, Koop DR, Gibbs A, Gao L, Flamiatos JF, Tucker E, Kleinschmidt R, Mori M
Published in Investigational New Drugs
Methodology
Single-arm phase II trial of 200 micromoles/day sulforaphane-rich extract in 20 men with recurrent prostate cancer.
Key Findings
Only one of 20 patients achieved the predefined PSA decline; the trial did not meet its efficacy threshold.
Conclusions
Sulforaphane extract showed no meaningful anti-tumour activity at this dose in recurrent prostate cancer.
Limitations
Single arm, no placebo, small sample, surrogate endpoint.
Supplements Studied
Sulforaphane extract showed no meaningful anti-tumour activity at this dose in recurrent prostate cancer.
Related Health Concerns
Study Details
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