Efficacy of soluble fibre, antispasmodic drugs, and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis
Black CJ, Yuan Y, Selinger CP, Camilleri M, Quigley EMM, Moayyedi P, Ford AC
Published in Lancet Gastroenterology & Hepatology
Methodology
Systematic review and network meta-analysis of 51 randomised controlled trials of fibre, antispasmodics including peppermint oil, and neuromodulators for IBS.
Key Findings
Peppermint oil ranked first for global IBS symptoms and abdominal pain relief among the antispasmodic class, though the quality of supporting evidence was low.
Conclusions
Peppermint oil is among the most effective antispasmodic options for abdominal pain and cramping in IBS, but the evidence base is of low quality.
Limitations
Indirect comparisons; older trials with poor reporting; short treatment durations.
Supplements Studied
Peppermint oil ranked first for global IBS symptoms and abdominal pain relief among antispasmodics, though evidence quality was low.
Outcomes Measured
Peppermint oil ranked first among antispasmodics for relief of abdominal pain and cramping in IBS.
Peppermint oil ranked first for global IBS symptoms and abdominal pain relief among the antispasmodic class, though the quality of supporting evidence was low.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.