A systematic review of St. John's wort for major depressive disorder
Apaydin EA, Maher AR, Shanman R, Booth MS, Miles JNV, Sorbero ME, Hempel S
Published in Systematic Reviews
Methodology
Systematic review of 35 randomized trials of St John's wort in major depressive disorder with quality appraisal.
Key Findings
St John's wort outperformed placebo and matched antidepressants in mild to moderate MDD, but evidence for severe depression and long-term use was insufficient.
Conclusions
Evidence supports use in mild to moderate MDD only; safety concerns centre on drug interactions.
Limitations
Heterogeneous preparations; few long-term or severe-depression trials.
Supplements Studied
Evidence supports use in mild to moderate MDD only; safety concerns centre on drug interactions.
Related Health Concerns
Study Details
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