Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract
Halaska M, Beles P, Gorkow C, Sieder C
Published in Breast
Abstract
Randomized controlled trial demonstrating vitex extract significantly reduced cyclical breast pain compared to placebo, with benefits appearing after 2 cycles and continuing to improve through 3 cycles.
Methodology
Randomized, double-blind, placebo-controlled trial over three menstrual cycles.
Key Findings
In women with cyclical mastalgia, a Vitex agnus castus solution reduced breast pain on visual analogue scale significantly more than placebo across three treatment cycles, with the difference emerging by the second cycle. Tolerability was comparable to placebo.
Conclusions
Vitex agnus castus provides modest short-term relief of cyclical breast pain relative to placebo.
Limitations
Small single-trial sample, three-cycle duration, subjective primary outcome, and manufacturer involvement in the study; the specific alcoholic extract limits generalization to other vitex products.
Study Details
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Disclosures
Funding
Supported by the extract manufacturer (Zeller/Strathmann).
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