Fisetin: A Dietary Antioxidant for Health Promotion
Khan N, Syed DN, Ahmad N, Mukhtar H
Published in Antioxidants & Redox Signaling
Abstract
Comprehensive review of fisetin covering antioxidant properties, anti-inflammatory effects, neuroprotection, and senolytic activity. Discusses mechanisms including SIRT1 activation and multiple signaling pathway modulation.
Methodology
Narrative review of preclinical in vitro and animal studies.
Key Findings
Reviews preclinical evidence that fisetin acts as an antioxidant and anti-inflammatory flavonoid, modulating SIRT1, NF-kB, PI3K/Akt and mTOR signalling, with neuroprotective and anticancer activity in cell and animal models. Typical dietary intake is far below the doses used experimentally, and oral bioavailability is poor.
Conclusions
Fisetin shows broad mechanistic promise in laboratory models, but no human efficacy data support supplementation.
Limitations
Narrative review of in vitro and animal work only; no controlled human trials, and effective concentrations in cell models often exceed achievable plasma levels.
Supplements Studied
Reviews preclinical evidence that fisetin acts as an antioxidant and anti-inflammatory flavonoid, modulating SIRT1, NF-kB, PI3K/Akt and mTOR signalling, with neuroprotective and anticancer activity in cell and animal models. Typical dietary intake is far below the doses used experimentally, and oral bioavailability is poor.
Outcomes Measured
Reviews preclinical evidence that fisetin acts as an antioxidant and anti-inflammatory flavonoid, modulating SIRT1, NF-kB, PI3K/Akt and mTOR signalling, with neuroprotective and anticancer activity in cell and animal models. Typical dietary intake is far below the doses used experimentally, and oral bioavailability is poor.
Study Details
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Disclosures
Funding
United States National Institutes of Health grants (University of Wisconsin authors).
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.