Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults
Bloemendaal M, Froböse MI, Wegman J, Zandbelt BB, van de Rest O, Cools R, Aarts E
Published in eNeuro
Methodology
Double-blind, counterbalanced, placebo-controlled within-subject fMRI study of acute tyrosine administration in healthy adults aged 61-72
Key Findings
Tyrosine did not alter reactive or proactive inhibition across the group, and with increasing age it worsened proactive response slowing and reduced fronto-striatal signal.
Conclusions
Acute tyrosine can have age-dependent detrimental neurocognitive effects, arguing against blanket dopamine-precursor loading in older adults.
Limitations
Very small sample, acute single-dose design, exploratory age-interaction analyses
Supplements Studied
Across the group, tyrosine did not alter reactive or proactive inhibition behaviorally but did increase fronto-parietal proactive inhibition-related activation.
Outcomes Measured
Tyrosine negatively affected proactive response slowing and associated fronto-striatal activation in an age-dependent manner.
Study Details
Access Study
Disclosures
Funding
Academic (Radboud University)
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