Effects and safety of periconceptional oral folate supplementation for preventing birth defects
De-Regil LM, Pena-Rosas JP, Fernandez-Gaxiola AC, Rayco-Solon P
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review of five randomized trials of periconceptional folate supplementation.
Key Findings
Folic acid supplementation reduced first-occurrence and recurrence of neural tube defects (RR 0.31); no clear effect on cleft palate, miscarriage or other birth defects.
Conclusions
Periconceptional folic acid prevents neural tube defects; benefits do not extend to other birth defects.
Limitations
Few trials, older studies, limited data on optimal dose and non-NTD outcomes.
Supplements Studied
Folic acid supplementation had a protective effect against neural tube defects (RR 0.31).
Outcomes Measured
Folic acid supplementation before and in early pregnancy produced a large protective effect against neural tube defects
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.