systematic_review
    2011

    Vitamin D and innate immune function: effects on monocyte and macrophage antimicrobial activity

    Hewison M

    Published in Nature Reviews Endocrinology

    Methodology

    Narrative and mechanistic review of human data on vitamin D signalling in monocytes and macrophages, including cathelicidin induction.

    Key Findings

    1,25-dihydroxyvitamin D induces cathelicidin in macrophages and enhances antimicrobial killing capacity in vitamin D-replete states.

    Conclusions

    Vitamin D status is a determinant of macrophage antimicrobial function.

    Limitations

    Mechanistic review; clinical infection endpoints not pooled.

    Supplements Studied

    Vitamin D
    Vitamin

    1,25-dihydroxyvitamin D induces cathelicidin in macrophages and enhances antimicrobial killing capacity

    Outcomes Measured

    Macrophage Function
    Primary

    1,25-dihydroxyvitamin D induces cathelicidin in macrophages and enhances antimicrobial killing capacity

    Immune Function

    1,25-dihydroxyvitamin D induces cathelicidin in macrophages and enhances antimicrobial killing capacity in vitamin D-replete states.

    Study Details

    Year:2011
    Quality Score:6/10

    Access Study

    View on DOIView on PubMedOriginal Source

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