Effect of Vitamin D on Depression: A Randomized Clinical Trial
Okereke OI, Reynolds CF, Mischoulon D, Chang G
Published in JAMA
Abstract
Large randomized trial examining vitamin D supplementation effects on depression incidence and mood outcomes.
Methodology
Ancillary study to a nationwide randomized, double-blind, placebo-controlled 2x2 factorial trial (VITAL).
Key Findings
In the VITAL-DEP ancillary trial of 18,353 adults aged 50+, vitamin D3 2,000 IU/day did not reduce the risk of incident depression or clinically relevant depressive symptoms compared with placebo (HR 0.97) and produced no meaningful difference in mood scores over a median 5.3 years.
Conclusions
Vitamin D supplementation does not prevent depression in generally healthy, mostly vitamin D-replete middle-aged and older adults.
Limitations
Population was largely vitamin D sufficient at baseline and not selected for depression risk; results do not address treatment of established depression or repletion in deficient individuals.
Supplements Studied
In the VITAL-DEP ancillary trial of 18,353 adults aged 50+, vitamin D3 2,000 IU/day did not reduce the risk of incident depression or clinically relevant depressive symptoms compared with placebo (HR 0.97) and produced no meaningful difference in mood scores over a median 5.3 years.
Outcomes Measured
Vitamin D supplementation influences neurotransmitter synthesis and brain function, supporting mental health and emotional well-being.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
National Institute of Mental Health / National Institutes of Health; study agents donated by Pharmavite.
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.