Kavalactone content and safety of kava preparations: a systematic review of clinical trial adverse-event data
Teschke R, Sarris J, Lebot V
Published in Phytomedicine
Methodology
Systematic review of kava preparation chemistry, extraction solvent and reported adverse events across clinical and post-marketing data
Key Findings
Hepatotoxicity reports clustered with acetonic and ethanolic extracts and poor-quality raw material rather than traditional aqueous preparations.
Conclusions
Preparation method appears central to kava liver safety, favouring aqueous noble-cultivar extracts.
Limitations
Retrospective causality assessment; confounding by co-medication.
Supplements Studied
Hepatotoxicity reports clustered with acetonic and ethanolic extracts and poor-quality raw material rather than traditional aqueous preparations.
Study Details
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