Vitamin B6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity
Hadtstein F, Vrolijk M
Published in Advances in Nutrition
Abstract
Review of the mechanisms and dose relationships of pyridoxine-induced sensory neuropathy.
Key Findings
Chronic high-dose pyridoxine intake is associated with dose-dependent sensory peripheral neuropathy; case reports exist below previously assumed safe thresholds.
Conclusions
Long-term supplemental vitamin B6 should be kept low; high-dose use requires monitoring.
Limitations
Narrative and mechanistic review; causality from case reports uncertain.
Supplements Studied
Chronic high-dose pyridoxine intake is associated with dose-dependent sensory peripheral neuropathy; case reports exist below previously assumed safe thresholds.
Related Health Concerns
Study Details
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