Remedy Routes
    systematic_review
    2023

    The impact of curcumin supplementation on systemic lupus erythematosus and lupus nephritis: A systematic review

    Ramessar N, Borad A, Schlesinger N

    Published in Lupus, Vol. 32 (5), pp. 644-657

    Methodology

    PRISMA systematic review (PubMed, Google Scholar, Scopus, MEDLINE) of curcumin supplementation in SLE and lupus nephritis, covering human trials, human in vitro studies and mouse models.

    Key Findings

    Three double-blind, placebo-controlled human trials were found, with 14 to 39 patients and 4 to 12 weeks of treatment. Curcumin lowered 24-hour and spot proteinuria, but C3, dsDNA and SLEDAI did not change. Mouse studies used much higher doses (12.5-200 mg/kg/day).

    Conclusions

    Data suggest a potential benefit, but no dose can be advised until long, large trials are done in SLE subgroups including lupus nephritis.

    Limitations

    Few, small, heterogeneous trials; most mechanistic data come from mice; no pooled estimate.

    Supplements Studied

    Curcumin
    Compound

    In human trials, curcumin decreased 24-h and spot proteinuria

    Curcumin is the active ingredient in the curry spice turmeric

    Related Health Concerns

    Lupus (SLE)

    Study Details

    Year:2023
    Quality Score:6/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.