Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials
Gorabi AM, Razi B, Aslani S, Abbasifard M, Imani D
Published in Cytokine, Vol. 143, pp. 155541
Methodology
Systematic review and meta-analysis of randomized trials of curcumin reporting inflammatory cytokines produced primarily by monocytes and macrophages.
Key Findings
Curcumin significantly lowered circulating TNF-alpha, IL-6 and CRP, markers dominated by macrophage activity.
Conclusions
Curcumin dampens macrophage-driven inflammatory signalling in humans.
Limitations
Bioavailability formulations differ; cellular macrophage phenotype rarely measured directly.
Supplements Studied
Curcumin significantly lowered circulating TNF-alpha, IL-6 and CRP
Outcomes Measured
Curcumin significantly lowered circulating TNF-alpha, IL-6 and CRP
Curcumin significantly lowered circulating TNF-alpha, IL-6 and CRP, markers dominated by macrophage activity
Study Details
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