Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides
Wurtman RJ, Cansev M, Ulus IH
Published in Journal of Nutrition, Health and Aging, Vol. 13 (3), pp. 189-97
Methodology
Review of human and animal studies of CDP-choline on phosphatidylcholine synthesis, dendritic spine density and synaptic membrane formation.
Key Findings
Citicoline increased brain phosphatide levels and dendritic spine density, supporting formation of new synaptic membrane.
Conclusions
Citicoline supplies substrate for synaptic membrane growth.
Limitations
Mechanistic emphasis; limited clinical endpoints.
Supplements Studied
Citicoline increased brain phosphatide levels and dendritic spine density
Outcomes Measured
Citicoline increased brain phosphatide levels and dendritic spine density, supporting formation of new synaptic membrane
Study Details
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