Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination
Willis MS, Monaghan SA, Miller ML, McKenna RW, Perkins WD, Levinson BS, Bhushan V, Kroft SH
Published in American Journal of Clinical Pathology
Methodology
Case series of three patients with cytopenias and marrow changes attributed to copper deficiency from excess zinc intake.
Key Findings
Excess zinc intake caused copper deficiency presenting as anemia and neutropenia with characteristic bone marrow findings that resolved with copper repletion.
Conclusions
High-dose zinc supplementation can precipitate clinically significant copper deficiency.
Limitations
Case series only, no control group, cannot estimate incidence.
Supplements Studied
Excess zinc intake caused copper deficiency presenting as anemia and neutropenia that resolved with copper repletion.
Related Health Concerns
Study Details
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