Fisetin, a flavonoid with potential health benefits: chemistry, bioavailability and pharmacology
Grynkiewicz G, Demchuk OM
Published in Acta Biochimica Polonica
Methodology
Narrative/systematic review of fisetin chemistry, pharmacokinetics and reported biological activity.
Key Findings
Fisetin has very low oral bioavailability and rapid conjugation, limiting achievable plasma concentrations relative to those active in vitro.
Conclusions
Formulation and bioavailability remain the central obstacles to translating fisetin research into human benefit.
Limitations
No clinical outcome data; review of heterogeneous preclinical literature.
Supplements Studied
Fisetin has low oral bioavailability and undergoes rapid conjugation, limiting plasma concentrations relative to in vitro active levels.
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.