Use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double-blind, controlled trial

Pregnant women were randomised to a cream containing hydroxyprolisilane-C, rosehip oil, Centella asiatica triterpenes and vitamin E or an identical cream without the active ingredients. Overall stretch mark incidence did not differ (37.6% treated versus 33.3% control, not significant), but severity of pre-existing stretch marks increased significantly in controls (17.8%, p = 0.001) and not in the treated group (6.3%). Among women who developed new marks, the rise in severity was smaller with treatment (0.14 versus 0.47, p = 0.031), and in women with no stretch marks at baseline incidence was 5.6% with treatment versus 35% with control (p = 0.031, OR 9.2, 95% CI 1.0-83.3).