Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials
Greff D, Juhász AE, Váncsa S, Váradi A
Published in Reproductive Biology and Endocrinology
Methodology
Systematic review and meta-analysis of 26 randomized controlled trials (1691 women with PCOS) comparing inositols with metformin or placebo, with cycle normalization as the primary outcome.
Key Findings
Women treated with inositol were 1.79 times more likely to achieve a regular menstrual cycle than controls, with favourable safety and fewer gastrointestinal effects than metformin.
Conclusions
Inositol supplementation improves menstrual cycle regularity in PCOS and is a reasonable, well-tolerated option.
Limitations
Heterogeneous inositol forms and doses, variable trial quality, and inconsistent definitions of cycle regularity.
Supplements Studied
In patients treated with inositols, the risk (CI: 1.13; 2.85) of having a regular menstrual cycle was found by 1.79 higher than in the control group.
Related Health Concerns
Study Details
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Disclosures
Funding
Not stated
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.