Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation
Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, et al.
Published in Osteoporos Int, Vol. 27 (1), pp. 367-76
Methodology
Meta-analysis from the National Osteoporosis Foundation of randomised controlled trials of calcium plus vitamin D and fracture, with a PubMed search from July 2011 to July 2015 and random-effects pooling.
Key Findings
8 trials, 30,970 participants, 195 hip and 2,231 total fractures. Calcium plus vitamin D reduced total fractures by 15% (summary RR 0.85, 95% CI 0.73 to 0.98) and hip fractures by 30% (0.70, 0.56 to 0.87).
Conclusions
The authors concluded the results support calcium plus vitamin D for fracture risk reduction in community-dwelling and institutionalised middle-aged to older adults.
Limitations
Used subgroup data from the Women's Health Initiative (women not taking personal supplements), as the authors note; few hip fractures; PubMed-only search.
Supplements Studied
Related Health Concerns
Study Details
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