Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial
Gowachirapant S, Jaiswal N, Melse-Boonstra A, Galetti V, Stinca S, Mackenzie I, Thomas S, Thomas T, Winichagoon P, Srinivasan K, Zimmermann MB
Published in The Lancet Diabetes & Endocrinology
Methodology
Randomised double-blind placebo-controlled trial (MITCH) of 200 micrograms iodine daily in mildly iodine-deficient pregnant women in India and Thailand with child neurodevelopment assessed at 5-6 years
Key Findings
Child IQ and neurodevelopmental scores at age 5-6 years did not differ between iodine and placebo groups despite improved maternal iodine status.
Conclusions
Iodine supplementation in mild deficiency did not improve child cognitive outcomes.
Limitations
Mild deficiency only; supplementation began in second trimester for many participants.
Supplements Studied
Child IQ and neurodevelopmental scores at age 5-6 years did not differ between iodine and placebo groups despite improved maternal iodine status.
Outcomes Measured
Child IQ and neurodevelopmental scores at age 5-6 years did not differ between iodine and placebo groups despite improved maternal iodine status.
Study Details
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